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Assessment of helical interfaces in proteinprotein interactions

Notably, when an acylated GCGR agonist was administered alone, it led to approximately 20% weight loss in mice on a high-fat diet, and this weight loss was further enhanced when the GCGR agonist was combined with a GLP-1R/GIPR co-agonist

However, the rate of endoscopic procedure interruption was higher in patients treated with GLP-1 RAs, possibly due to increased gastric contents

GIP consists of 42 amino acids and is synthesized and secreted by endocrine K cells located mainly in the proximal duodenum and jejunum

doi: 10.1016/j.diabres.2024.111675, 3

This likely reflects the glucagon receptor activation increasing sympathetic tone and thermogenesis, the same mechanism that drives the additional metabolic benefits