glp 1 agonist alzheimer Incretin and insulin signaling as novel therapeutic targets for Alzheimer's and Parkinson's disease GLP-1 mimetics and cognition -

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The authors also suggest a second potential pathway independent of GLP-1 for some of the cardiovascular effects

Zoe Lees (PhD)

Verma S, McGuire DK, Bain SC et al

This is further supported by the near-complete absence of cardiac Glp1r mRNA in Glp1r Tie2/ mice (57), suggesting that mouse cardiac Glp1r expression is primarily contributed by endothelial cells and/or immune cells

Metseras portfolio included both oral and injectable incretin, non-incretin, and combination therapy candidates, with four programs in clinical development and several programs with investigational new drug-enabling studies ongoing