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Similarly, 21% of patients with MASLD and diabetes/obesity began GLP-1 therapy within six months, again outpacing those without the comorbidity

Semaglutide added to basal insulin in type 2 diabetes (SUSTAIN 5): a randomized, controlled trial

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Purpose-built for physicians GLP-1 therapy may reduce suicidal ideation risk for adolescents with obesity Key takeaways: Adolescents with obesity were less likely to have suicidal ideation or a reported suicide attempt if they were prescribed a GLP-1

placebo and showed substantial and sustained reductions in body weight as well as improvement in lipid parameters

Nonetheless, pharmacological therapeutic development for MAFLD based on the mechanisms of action, adverse events, and efficacy is reviewed and recommended in clinical practice guidelines (CPGs) issued by the liver international society in the Americas (AASLD), 6 Europe (EASL), 12 and Asia (APASL)