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Histone deacetylases (HDAC2), a member of the HDAC family, is correlated with insulin signaling components in postsynaptic glutamatergic neurons of the adult mouse hippocampus, and hyperactivity of the HDAC system (including HDAC2) may result in the suppression of the insulin signaling system and consequent disruption of synaptic plasticity in type 2 diabetes.137 GLP-1 RA has a definite effect on improving synaptic plasticity

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Kathryn Giblin, Mary Angelyn Bethel, Amy Lalonde, Nadia Ahmad and Qiwei Wu are employees and shareholders of Eli Lilly and Company