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CONCLUSION The benefits of GLP-1 agonists in appropriate patient groups remain significant

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This finding aligns with previous studies, suggesting that short-acting agents may more readily cross the blood-brain barrier, thereby activating central GLP-1 receptors and exacerbating symptoms such as nausea and anorexia (Levin et al., 2017)

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2B) to the point where a dose-response curve and half-maximal effective concentration (EC 50 ) could be defined