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The biggest difference is how the medication gets into your bloodstream

the binding mode, signaling bias, pharmacokinetics, and species-specificity sections below show why that is false

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Mikhailidis Current Pharmaceutical Design.2019

Among 26,944 adults with type 2 diabetes, there were 1848 individuals in the GLP-1RA group, 5034 in the SGLT-2i group, 4813 in the insulin group and 15,249 in the miscellany group (Table 1)