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Furthermore, the number of neuron-derived orphan receptor 1 (NOR1) which can modulate VSMC proliferation, is decreased by GLP-1RAs in a dose-dependent manner in mice [121]

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It is administered once weekly by injection, with doses that begin low and increase over a span of weeks

Abbreviations ACC: American College of Cardiology ADA: American Diabetes Association ASCVD: Atherosclerotic cardiovascular disease BMI: Body mass index CI: Confidence interval CV: Cardiovascular CVD: Cardiovascular disease CVOT: Cardiovascular outcomes trial DPP-4: Dipeptidyl peptidase-4 EASD: European Association for the Study of Diabetes EDTA: European Dialysis and Transplant Association eGFR: Estimated glomerular filtration rate ERA: European Renal Association ESC: Europe Society of Cardiology ESRD: End-stage renal disease EURECA-m: European Renal and Cardiovascular Medicine FDA: U.S

Diabetologia (2009) 52:199207

Across the SURPASS program, tirzepatide reduced SBP vs