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These include short-acting agents (e.g., exenatide BID), long-acting formulations (e.g., liraglutide, semaglutide, dulaglutide), dual agonists such as tirzepatide (GIP/GLP-1 RA), and novel oral agents like orforglipron and danuglipron

The most concerning feedback relates to effectiveness

After 52 weeks patients continued on the once weekly exenatide maintained an A1C improvement (2.0%) while those switching from twice daily to once weekly further reduced A1C to achieve a similar reduction in A1C as those originally on exenatide once weekly

Early signs that a dose adjustment might be needed

[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Mardinoglu A., Wu H., Bjornson E., et al