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S5 demonstrates that we successfully inserted the PSR-MNs to the animals skin, since only a few MNs (less than 3%) were left on the patches after the skin administration

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At 8:30 am and at 12:00 pm, standardized, savory meals were provided (consisting of 116 g carbohydrates, 60 g fat, 25 g protein, 12 g fiber, and 5.7 g salt, for a total of 1284 kcal)

It enhanced autophagy, prevented synapse loss, improved insulin signaling, and restored neurovascular integrity

Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice

Practical considerations such as injection frequency, needle size, and gastrointestinal tolerability may also influence individual patient selection