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In addition to this, GLP-1RAs may directly improve hepatic steatosis via the upregulation of fatty acid metabolism and insulin signalling pathways [12]

Preclinical studies have suggested that GLP-1 receptors may be expressed on osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells), primarily in animal models

JAMA 2021;325:1403-13.ArticlePubMed 32

The decrease is approximately 150 kcal per day less than predicted by standard metabolic models, suggesting GLP-1 medications partially protect against the severe metabolic slowdown seen with dieting alone
