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Yet, the actual risk of metformin-associated lactic acidosis (MALA) appears to be extremely rare (approximately 3 cases per 100,000 patient-years)

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FDA has raised specific concerns about compounded semaglutide, including adverse events tied to dosing errors and the use of salt forms (semaglutide sodium, semaglutide acetate) that differ from the semaglutide base in FDA-approved drugs
Research from the Employee Benefit Research Institute found that covering GLP-1s through insurance could raise employer premiums by as much as 14%, even when access was limited to the highest-need patients
