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Insights from CREDENCE trial indicate an acute drop in estimated glomerular filtration rate during treatment with canagliflozin with implications for clinical practice

Thus, regardless of our understanding of the physiology or pathophysiology of islet produced GLP-1, these data suggest that this pool of GLP-1 could be targeted to treat T2DM and avoid some of the CNS side-effects (i.e., nausea) associated with long-acting GLP-1 agonists

63% of patients achieved more than 20% weight loss compared to 1% on lifestyle changes alone

This keeps you feeling full longer and prevents a rapid spike in blood sugar after meals
