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About this article Cite this article Yi, T.W., Sridhar, V.S., Scott, J

R.PrezC.HijikataA.FujimuraY-i.EndoT.et al

9 November 2023

After 24 h, the transfected cells were seeded onto 384-well microtiter plates (3000 cells per well) in HBSS supplemented with 5 mM HEPES, 0.1% (w/v) bovine serum albumin (BSA) and 0.5 mM 3-isobutyl-1- methylxanthine, and stimulated with increasing concentrations of GLP-2 for 30 min at RT

doi: 10.1038/srep33251 30 TeedeHJKhomamiMBMormanRLavenJSEJohamAECostelloMFet al

These differences can be attributed to species-specific variations in drug metabolism, which alter systemic exposure, as well as potential differences in GLP-1 receptor expression and activity across species