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Metabolism The metabolism of common GLP-1 RAs varies across agents: Exenatide undergoes hydrolysis in the kidneys and liver, producing smaller inactive peptides excreted via the kidneys (23)

comparative effectiveness and safety of bariatric procedures for weight loss: a PCORnet cohort study

It is also important to note that CONTRAVE can cause a false-positive urine drug screen for amphetamines

To learn more about how to monitor and protect renal function during incretin research, read our GLP-1 Peptides Complete Guide 2026

Illustrative Cases High Triglycerides: A 58-year-old man with poorly controlled diabetes (A1c 9.2%) and moderate triglyceride elevation started semaglutide

( 10.1016/j.atherosclerosis.2017.06.920) [DOI] [PubMed] [Google Scholar] 31.Chai W, Dong Z, Wang N, Wang W, Tao L, Cao W, Liu Z