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Some of the insulin travels to the hypothalamus area of the brain, deactivating sensations of hunger

The worst period is weeks 1-12 during dose titration

Interestingly, this connection between peripheral and central GLP-1 secretion may play a significant role in GLP-1 enhancement of the insulin response

Dehydration is common on these drugs due to reduced appetite and GI side effects

The MHRA has approved these agents for specific indications, and NICE provides guidance on their use within the NHS, typically recommending them when other treatments have proven insufficient or when specific clinical criteria are met

He said the coverage will save the state money in the long run to lessen the risk of chronic conditions related to obesity