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Han, Y., Kwon, E
Even brief periods of discontinuations or interruptions might progressively erode and could ultimately reverse this protection, increasing the risk of cardiovascular events, the researchers wrote

pipelinereview.com
J.MolanderA.LinnetK.PtitoM.Fink-JensenA

Studies are still happening to understand why. The data from Dandelion Health showed that the 10% of people with the best response to GLP-1s had results that mirrored what clinical trials found, but the 10% with the least success with the treatments had no weight change, or even an increase in weight, over time