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[DOI] [PMC free article] [PubMed] [Google Scholar] [121].Lisco G, De Tullio A, Disoteo O, et al

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Crucially, none of these studies utilized adjudicated endoscopic assessments, meaning true reparative mucosal healing could not be verified (101, 103)

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NICE guidance (NG28) recommends GLP-1 receptor agonists for adults with type 2 diabetes according to specific criteria, including BMI thresholds and previous therapy response

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The vagus in turn stimulates second order neurons in the NST (128, 129), located in the medulla of the brainstem ( Figure 1 )

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However, another parameter associated with bone formation (ALP levels) was unchanged (Pacheco-Pantoja et al., 2011)

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Evidence references ADJUNCT ONE, PMID 27506222 ADJUNCT TWO, PMID 27493132 ADJUST T1D, PMID 40550013 Semaglutide crossover study, PMID 39794615 Tirzepatide observational data (Shah 2024), PMC11571402 Shah discontinuation post-hoc (ADJUNCT I/II), PMID 39717993 Shah 2025, GLP-1RA / tirzepatide in T1D with severe early (genetic) obesity ( JDST ) Insulin titration paper, PMID 39829697 Adjunct therapy review, PMID 40618954 Bone health review, PMC8118128 Weight loss and bone, PMID 38916894 Consensus and guidelines: ADA Standards 2025, PMID 39651989 ISPAD 2024, PMID 39657603 GLP-1 AID consensus, PMID 39517127 Related reading on GNL This Episode 17 conversation was the inspiration for the four-part Adjunctive Therapies guide built on top of the April 2026 evidence update

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