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For comparison: This is not a formulation problem that better engineering can easily solve

Beyond absolute oxidative rate, mitochondrial resilience depends on spare respiratory capacitythe difference between basal and maximal electron transport fluxwhich reflects the ability to accommodate additional energetic demand without redox disequilibrium [64, 65]

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The HK-2 cells were plated in 0.01% poly-L-lysine (Sigma-Aldrich)-coated glass slides at a density of 1.5104 cells/slide (area, 1.8 cm2), cultured for 1 day, and finally treated for 72 h in medium containing either a 5.5 or 40 mM glucose concentration