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Although the primary biological actions ascribed to intact GLP-1 are mediated by a single GLP-1 receptor [28], GLP-1 is rapidly cleaved by the enzyme dipeptidyl peptidase-4 (DPP-4) into GLP-1(9-36) [29], which exhibits its own biological activities (albeit not insulin secretion any more) [30,31], and thus intact GLP-1 exhibits a short half-life of one to two minutes in the circulation [32]

Weight regain after discontinuation is common, with studies showing 60-70% of lost weight returning within a year of stopping

Dao et al., 2016

This narrative review describes the clinical syndrome, pathophysiology, diagnosis and reports on standard and pragmatic therapeutical treatment options in order to improve the clinical outcome of patients with dumping syndrome

They also found that blocking its brain release in normal animals prompted them to eat more

Mounjaro (Tirzepatide): This drug takes it a step further as a dual GIP and GLP-1 receptor agonist