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13 Further research is needed to investigate the interconnected pathophysiologic roles of glucagon, GLP-1, and GIP while determining the niche for twincretin therapy in T2DM

Disrupted calcium homeostasis impairs metabolic enzyme activity and activates cell-death pathways (65)

Side effects are virtually identical because the active ingredient is the same

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Results show that GLP-1RA users, defined as individuals with a history of use exceeding six months and with at least two refills within six months prior to the procedure, experienced a higher incidence rate of aspiration pneumonia (0.83%) compared to nonusers (0.63%), corresponding to a hazard ratio of 1.33