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Self-insured plans offered by larger employers and administered by Blue Cross may be influenced by the policy change but have more flexibility since they pay their own claims

Side effects at the tirzepatide starting dose are generally manageable but more noticeable than semaglutide because of the additional GIP receptor activation

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Missed doses and frequent medication switches can affect side effects and stability during screening

These molecules elicited additive effects to reduce weight and improve glucose control beyond the loose combination of pharmacokinetically and potency-matched GLP-1R and GIPR mono-agonists