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People taking the highest dose of tirzepatide lost nearly 18% of their body weight

Are GLP-1s approved to treat high blood pressure
When gut health declines, GLP-1 secretion weakens cravings increase and metabolism slows

Fralick M, Kim SC, Schneeweiss S, Everett BM, Glynn RJ, Patorno E
doi: 10.1038/nature24042 96 DayEAFordRJSmithBKMohammadi-ShemiraniPMorrowMRGutgesellRMet al

In mice, GLP-1R-positive cells were identified in several regions of the telencephalon (olfactory bulb, amygdala, preoptic area, nucleus accumbens, septum), diencephalon (hypothalamic arcuate nucleus, paraventricular nucleus, dorsomedial nucleus, the lateral hypothalamic nucleus and the supraoptic nucleus) and regions of the mesencephalon [393]
