microdose oral semaglutide GLP-1s What is semaglutide? Exploring Ozempic,

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To our knowledge, this is the first reported case suggesting the potential role of GLP-1 receptor agonists in slowing the progression of localized scleroderma, possibly due to their anti-fibrotic and anti-inflammatory effects.

Herein, we reported a newly developed synthetic route of semaglutide that is simple and efficient, based on a soluble hydrophobic-support-assisted liquid-phase synthetic method by applying Alloc-chemistry to the synthesis of the main chain peptide and side chain peptide of semaglutide

Finally, we presented our insights on clinical concerns such as appropriate trial endpoints, management of comorbidities, and future developments

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