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For patients at low cardiovascular risk, metformin remains a trusted and effective option
21 The MAESTRO-NASH trial 2224 reported that steatohepatitis resolved without worsening of fibrosis in 25.9% of patients receiving resmetirom 80 mg and in 29.9% of those receiving 100 mg, compared with 9.7% in the placebo group, and fibrosis improved without worsening of steatohepatitis in 24.2% and 25.9%, respectively, compared with 14.2% with placebo
Sun H, Sivasubramanian R, Vaidya S, Barve A, Jarugula V
The advantages of the triple agonist were also reflected in the MASLD (magnetic resonance-observed substantial loss of liver fat): approximately 90% of high-dose retatrutide subjects in a subgroup of 98 people had a normal fat content restoration
NCT04093752) and insulin lispro (ClinicalTrials.gov registration no
Together, these findings provide evidence for the beneficial effects of incretin-based therapies for kidney function in populations without diabetes
