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Wegovy is contraindicated during pregnancy, and for all semaglutide products, discontinuation is recommended at least 2 months before a planned pregnancy due to the long half-life of the medication
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Interestingly, a recent study by the Mandrup laboratory has shown that exposure to high glucose (25 mM) elicits a biphasic response in INS-1E cells 43
43 The Semaglutide Treatment Effect in People with obesity (STEP) Program trials, with semaglutide 2.4 mg and lifestyle intervention, showed weight reductions of 14.717.4% on average in persons with pre-obesity or obesity (without diabetes), with improvements in cardiometabolic risk factors and sustained effects for two years (Table 2)
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