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Fourth Edition14 Montoya A, Bruins R, Katzman MA, Blier P

The ability of GLP-1 RAs to passivate or stabilise plaque requires further evaluation in human studies but may be a novel and important mechanism by which this class confers a reduced risk of future and recurrent ischaemic events, including both MI and ischaemic stroke

Four preclinical studies in obese mice

Some patients notice appetite changes within the first few weeks, but meaningful weight loss usually develops over months

Peer review Peer review information Nature Chemical Biology thanks Alejandra Tomas and the other, anonymous reviewers for their contribution to the peer review of this work

Wegovy contains the same main ingredient as Ozempic, semaglutide, and is FDA-approved for weight loss in people with obesity or who are overweight with at least one weight-related condition