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This review synthesizes animal and clinical evidence on leptins role in obesity, focusing on models such as genetically deficient mice (e.g., ob/ob , db/db ), diet-induced obesity mice, and clinical conditions such as congenital leptin deficiency (CLD), leptin receptor deficiency (LRD), lipodystrophy, and common obesity

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Despite the underlying mechanisms of such findings remaining a matter of theoretical postulation [60, 110112, 124], the contribution of CVOTs as new evidence to the diabetes treatment armamentarium highlights a new era of standard treatment practices

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