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In the subgroup at high cardiovascular risk, effect estimates were similar (HR 0.80, 95% CI 0.71 to 0.91)

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They observed a body weight loss difference of 2.9 kg between tirzepatide and GLP-1 RAs, although the specific GLP-1 RA was not identified, limiting direct comparison with our study

For the vast majority of patients, the immense, proven systemic benefits of GLP-1 medications, such as reversing severe obesity, stabilizing high blood sugar, reducing the risk of stroke, and preventing kidney failure, far outweigh this rare visual side effect
