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Among those who had a measurement, the absolute change was calculated as the difference to the last value available before treatment initiation in mmol/mol for HbA1c, mL/min/1.73 m 2 for eGFR, and mmol/L for lowdensity lipoprotein (LDL) cholesterol, and triglycerides

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Pregnancy was confirmed by the presence of a vaginal plug, which was recorded as E0 (embryonic day 0)