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Depression but not non-persistence to antidiabetic drugs is associated with mortality in type 2 diabetes: a nested case-control study

The Type 2 Diabetes Mellitus segment accounted for the maximum share of over 55.5% by application in 2025 due to the high global disease burden resulting in rising demand for efficacious therapies for glycemic control

And then reports of NAEs associated with GLP-1 RAs were filtered

Animal model studies have suggested that GLP-1RAs may cause pancreatitis and exocrine dysplasia, but in the large RCTs and a meta-analysis, GLP-1RAs did not increase the risk of pancreatitis or pancreatic cancer [82,83]

The extract of Gordonii and its active component, Gordonosides F, promoted glucose-dependent GLP-1 and insulin release, demonstrating a blood glucose-lowering action during the oral glucose tolerance test (OGTT)

In human NCI-H716 cells, GLP-1 secretion is stimulated by bethanechol, a nonselective muscarinic agonist, while pretreatment with pirenzipine or the M2 antagonist gallamine inhibits bethanechol-induction of GLP-1 secretion [336]