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Researchers at UTHealth Houston described orforglipron's potential to become "the Metformin of obesity", a widely accessible, affordable, and scalable first-line treatment

Created for the treatment of diabetes, it binds to receptors in the body and diabetics create a hormone known as incretins that help regulate the body and the sugars in the body

placebo Most effective in IBS-C & IBS-M patients Well-tolerated with no major side effects Phase 2a results ROSE-010s Effect on IBS Motility GI Transit Study (Camilleri et al.) Findings: Small intestine transit time increased Colonic transit time decreased Potential to improve IBS-C & IBS -M symptoms Whats Next

Recognizing Lean Liver Disease in Clinical Practice Clinicians should consider metabolic liver disease in patients who present with: Normal BMI but central adiposity (increased waist circumference) Mildly elevated liver enzymes without a clear cause Dyslipidemia or insulin resistance features Fatty liver on incidental imaging Routine use of noninvasive tests such as FIB4, ELF score, or transient elastography can help stratify risk and guide hepatology referrals

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