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Furthermore, growing evidence shows sex differences in the medical consequences of these chronic diseases, including obesity-related conditions like obstructive sleep apnea and heart failure [51], and AUD-related conditions like ALD [46]

PIONEER 8 trial was done in the late stage of diabetes in patients already on different types of insulin.[21] All doses of oral semaglutide showed a significant reduction in HbA1c and weight in comparison to placebo at weeks 26 and 52