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The analysis of 4887 participants treated with tirzepatide and 2,328 participants in the control groups identified 142 participants who developed at least one MACE-4p (inclusive of cardiovascular mortality, myocardial infarction, stroke, and hospitalization for unstable angina) and confirmed the cardiovascular safety with an hazard ratio (HR) of 0.80 (95% CI 0.571.11) for the comparison between tirzepatide and controls

Nausea affects a significant portion of patients (up to 2050% early on), along with possible vomiting, diarrhea, or constipation

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(Lausanne) 11 , 178 (2020)

Journal of Controlled Release, 336 , 310-321