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GLP-1 Receptor Agonist Use Linked to Higher Risk for Ischemic Optic Neuropathy THURSDAY, July 16, 2026 -- Use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) is associated with a higher risk for ischemic optic neuropathy (ION) compared with
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150,151,152,153 In animal models with reduced F/B ratios, the expression of mucin and ZO-1 in the intestinal barrier, as well as the expression of anti-inflammatory factors, is increased, whereas the expression of the proinflammatory cytokines TNF-, IL-1, and IL-6 is inhibited, and disease symptoms are largely reversed
Second, considering the biological latency of GLP-1 RAs as well as the potential underdiagnosis of DR at baseline, we, therefore, undertook the analysis by excluding patients with less than 6 months of follow-up
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