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During its use, reliable contraception is essential to avoid unintended exposure

The most common AEs recorded following administration of PF-06882961 were nausea, vomiting, and decreased appetite, all of which were considered treatment-related by the investigator and consistent with the expected effects of the GLP-1R agonist mechanism

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SR18 exhibited an average hydrodynamic diameter of 4.001 nm with a polydispersity index (PDI) of 0.2289, indicating a relatively uniform and predominantly monomeric population in 1 X PBS, compared to 10 M BSA (hydrodynamic diameter 7.631 nm and PDI 0.1645) as shown in Supplementary Figure S5

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