retatrutide triple hormone receptor agonist metabolic for dysfunction-associated steatotic liver disease: a randomized phase 2a trial Retatrutide vs Mounjaro: triple agonist

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[DOI] [PMC free article] [PubMed] [Google Scholar] 85.Powell-Wiley T.M., Poirier P., Burke L.E., Desprs J.-P., Gordon-Larsen P., Lavie C.J., Lear S.A., Ndumele C.E., Neeland I.J., Sanders P., et al

Preclinical studies have shown that GLP-1RAs play a role in the immunomodulation of atherosclerosis, affecting multiple pathways involved in plaque development and progression

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Semaglutide restored GSK3-Drp1 signalling, maintained mitochondrial membrane potential, and decreased mitochondrial fragmentation in primary cardiomyocytes via GLP-1R activation