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Even under identical caloric prescriptions, semaglutide produced a 16.0 % weight loss by week 68 compared to 8.0 % with placebo, further supporting the additive pharmacologic effects of GLP-1 therapies beyond dietary and physical activity adherence

Understanding why weight regain happens after discontinuing GLP-1 treatment could be crucial for determining their long-term health impacts and the best way to prescribe them in the future
Comparison of treatment with sitagliptin or sulfonylurea in patients with type 2 diabetes mellitus and mild renal impairment: a post hoc analysis of clinical trials

2022;13:p

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