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This comparison examines whether retatrutide's triple agonist mechanism offers clinically meaningful advantages over semaglutide's proven single-agonist approach, while acknowledging the fundamental asymmetry in evidence quality between a fully approved drug and an investigational compound

By systematically searching both PubMed, Embase, Cochrane, and Scopus and including only randomised controlled trials with at least 12 weeks of followup, we ensured methodological rigour and internal validity

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