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FDA labeling indicates no clinically relevant pharmacokinetic changes across the spectrum of hepatic impairment (Child-Pugh classes A-C), and no dose adjustment is recommended based on hepatic function

These analogues are primarily used to treat type 2 diabetes and obesity

Read our preprint for a deeper discussion of our study design and results, or fill out the form to download our white paper.

Bis-IndoleDerived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells

Forest plot of Efpeglenatide versus comparators on the risk of overall Respiratory diseases

injections of 100 nmol kg 1 MK-801 ( n = 7 mice and n = 4 cages), 100 nmol kg 1 GLP-1 ( n = 6 mice and n = 3 cages), 100 nmol kg 1 , GLP-1MK-801 ( n = 6 mice and n = 3 cages), co-administration of 100 nmol kg 1 GLP-1 and 100 nmol kg 1 MK-801 ( n = 6 mice and n = 3 cages) or vehicle (isotonic saline, n = 7 mice and n = 4 cages) for 14 days