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At very low bioavailability, GI effects may be reduced simply because the peptide is not reaching effective concentrations anywhere in the body, including the brain

Over-the-counter antidiarrheal medications like loperamide can be used judiciously for diarrhea (avoiding use if fever, blood in stool, or infection is suspected), though patients should consult their healthcare provider before regular use

Refrigeration only slows further degradation

Excessive lipogenesis can lead to the accumulation of fat in the liver (hepatic steatosis) and other tissues, contributing to obesity and metabolic syndrome

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Food vs pills: cost and effectiveness comparison Whole foods provide superior nutrition at lower costs than supplements, with better absorption and additional health benefits