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These medications, initially developed for managing type 2 diabetes, are now widely recognized for their ability to suppress appetite, regulate blood sugar, and promote significant weight loss

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As the table below shows, GLP-1s claimed the top two spots in 2024 drug spending and accounted for more than one-third of the top 10 drugs overall

This incretin effect is considerably attenuated in people with type 2 diabetes (see Figure 1), a loss that is even considered an early indicator of the disease, but it was observed that this deficit could be completely corrected by the continuous infusion of GLP-1 to diabetic patients

HernandezAFGreenJBJanmohamedSD'Agostino RBSrGrangerCBJonesNPet alAlbiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (harmony outcomes): a double-blind, randomised placebo-controlled trial