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Patients stopping semaglutide or tirzepatide regained a pooled mean of 9.69 kg , with weight regain proportional to original weight lost

The discovery of GLP-1 has markedly changed the treatment options for people with type 2 diabetes and obesity, with a treatment effect that includes both better regulation of blood glucose and significant weight loss, while reducing the risk of complications arising

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These agents act on multiple physiological pathways involved in type 2 diabetes with the effect of increasing insulin secretion and decreasing glucagon to control glucose levels (1,2)

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