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Electronic databases including PubMed, Embase, and Web of Science were searched from inception until August 2025 using keywords such as GLP-1 receptor agonist, diabetic retinopathy, glaucoma, age-related macular degeneration, ocular disease, and neuroprotection. The search focused on identifying preclinical studies, large-scale retrospective cohort studies, and post-hoc analyses of major clinical trials that evaluated the utility and potential mechanisms of GLP-1RAs in ophthalmic diseases

GLP-1 Analogue Improves Hepatic Lipid Accumulation by Inducing Autophagy via AMPK/mTOR Pathway

Although approved for type 2 diabetes, Ozempic became widely associated with the broader GLP-1 boom because of its impact on body weight and metabolic outcomes

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For example, the RNA sequencing analysis on isolated enteroendocrine cells from obese individuals with or without T2DM revealed decreased expression of the PCSK1 gene in the jejunal epithelium, contributing to the biosynthesis of GLP-1 [32]

Clinicians should treat adherence to GLP-1 treatment as an important outcome in its own right not an afterthought, Al-Aly said