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Lillys Selective Amylin Agonist, Eloralintide, Demonstrated Meaningful Weight Loss and Favorable Tolerability in a Phase 2 Study of Adults with Obesity or Overweight

doi: 10.1097/MD.0000000000035394 68 RajagopalSAlruwailiFMavratsasVSernaMKMurthyVLRajiM

Recently recognized as a disease by the American Medical Association and other medical societies, obesity has grown in prevalence in the United States and around the world

The elevated cAMP activates two primary pathways: Protein Kinase A (PKA) and Exchange Protein directly Activated by cAMP (EPAC)
The development of GLP-/GIP dual agonists provides a more complete scheme for the treatment of metabolic diseases, but the safety of more dual agonists or multiple agonists in clinical trials is also worthy of attention

These findings provide comprehensive information to move into Phase 3 development and reinforce alenigliprons potential to become a backbone oral small molecule therapy for obesityone that is accessible, scalable, and combinable
