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Intramuscular injection causes semaglutide to absorb much faster than intended, which can increase side effects like bloating , dizziness , and fatigue while potentially reducing the duration of the medication effect between doses

Importantly, sudden onset of unilateral swelling, especially with pain, warmth, or redness, requires urgent medical evaluation to rule out deep vein thrombosis or acute infection

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Summary: There is no clinically superior day to start GLP-1 receptor agonist therapy, but beginning at a weekend or during reduced commitments allows time to monitor initial side effects

Semaglutide (Wegovy) is FDA-approved for weight management and is widely available across the EU, UK, Australia, and Canada