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For maximum effectiveness, retatrutide may surpass tirzepatide but is not yet FDA-approved

Topiramate has similar benefits for weight reduction in psychiatric patients, but cognitive impairment limits its usage (McIntyre RS et al, Am J Psychiatry 2024;181(1):2638)

Dysfunction in insulin signaling due to hypoinsulinemia, hyperinsulinemia, or insulin resistance leads to impaired glucose uptake, neurotransmitter imbalance, oxidative stress, mitochondrial dysfunction, ion-channel alterations, neuroinflammation, and disruption of the blood-brain barrier, ultimately enhancing neuronal hyperexcitability and seizure susceptibility

This hormone helps regulate blood sugar and slow down digestion, meaning users feel fuller (or satieted) and eat less

The result: you stay satisfied longer, eat less, and keep blood sugar stable

The models of the tirzepatideGLP-1RG s complex and peptide 20GLP-1RG s complex were built using the cryo-EM structure of the GLP-1GLP-1RG s complex (PDB code: 618) 27 as the starting point