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Unlike other GLP-1R agonists, NLY01 does not desensitize the GLP-1 receptor, allowing for continuous activation

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This lack of oversight means that compounded GLP-1 drugs can vary widely in terms of dosage, purity, and safety

GLP-1R positive nerve fibres (Abcam antibody, left panels) and PGP9.5 (right panels) in mucosal sigmoid colon biopsy specimens, from topcontrol, middle and bottomIBD, magnification x40

Another oral, non-peptide GLP-1 RA (lotiglipron) has also been withdrawn from development as in early phase clinical trials resulted in elevated liver enzymes which could indicate liver toxicity [30]