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Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node GLP-1 has direct chronotropic effects on the heart mediated by GLP-1 receptors in pacemaker cells of the sinus node, inducing changes in action potential morphology

Sildenafil (Viagra) is a phosphodiesterase type 5 (PDE5) inhibitor commonly used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH).

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