glp-1 mimetics Mechanisms by which agonists may exert beneficial effects on the GLP-1 Agonist Effects on Glucagon

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Following T-cell activation GLP-1R expression increased significantly, particularly in CD8 + T cells ( / mice could induce a significant increase in peripheral lymphocytes, but significantly reduced the percentage of CD4 + CD25 + FOXP3 + Tregs, and had no effect on cell apoptosis and migration ( / mice exhibited immunomodulatory effects, increasing tissue infiltration of neutrophils and T cells

Zhou Z, Chen X, Sheng H, Shen X, Sun X, Yan Y, et al

doi: 10.1007/BF00417698

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