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Cardiovascular Effects Dose-dependent increases in heart rate were observed with retatrutide: Heart rate increases peaked at approximately 24 weeks Gradually declined thereafter while remaining elevated above baseline This pattern is similar to that observed with other GLP-1 receptor agonists[4] The clinical significance of these heart rate changes requires further evaluation in larger and longer-term studies

The American Society of Anesthesiologists (ASA) recommends withholding these drugs before surgery, but definitive guidelines remain unclear

Explore a thorough comparison of Semaglutide and other GLP-1 receptor agonists

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AN is obesity's metabolic bookend. That connection explains why GLP-1 agonists carry serious risks for those predisposed to AN and with at least one in eight American adults now taking these drugs, the stakes couldn't be higher